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“Ribonucleotides are simply an expression of the fundamental principles of organic chemistry. They’re doing it unwittingly. The instructions for them to do it are inherent in the structure of the precursor materials. And if they can self-assemble so easily, perhaps they shouldn’t be viewed as complicated.” – John Sutherland

Fresh Reads from the Science 'o sphere!

Latest Influenza A (H1N1) News

Tuesday, July 31, 2007

Photo Gallery Three

More arty snapshots of life in Singapore, with the usual Fresh Brainz-style of quirkiness.


















Archway to the sky
(2007) Sony DSC-S600
















Big balloon
(2007) Sony DSC-S600











Hang on!
(2007) Sony DSC-S600













Lightdance
(2007) Sony DSC-S600
















Lines & curves II
(2007) Sony DSC-S600







Moonrise over Orchard
(2007) Sony DSC-S600










Ribbons in the sky
(2007) Sony DSC-S600
















Shadow of wealth and power
(2007) Sony DSC-S600











Symmetry
(2007) Sony DSC-S600







The big pour
(2007) Sony DSC-S600
















Triangles in bloom
(2007) Sony DSC-S600


Would you like to know more?

-
VivoCity Photo Gallery
-
Photo Gallery One
-
Photo Gallery Two

Fresh Science 31 July 2007

We do the hard work of exploring the globe for the sweetest science articles - so you don't have to.

But can they heal my irony gland? /Fantastically bright bolide over Europe (Bad Astronomy - USA)












The controversial state of 'hands on' sex therapy (Mind Hacks - USA)

Anomalokarisu! (Pharyngula - USA)

Monday, July 30, 2007

Fresh Science 30 July 2007

We do the hard work of staking out the globe for the sneakiest science articles - so you don't have to.

The discovery of XDR-TB (Aetiology - USA)















Reprogramming mammalian cell motility (Bayblab - Canada)

Academia is a cult (Bug Girl's Blog - USA)

Makes me feel tingly all over (Total Drek - USA)

Friday, July 27, 2007

Fresh Science 27 July 2007

We do the hard work of nitpicking the globe for the most sizzling science articles - so you don't have to.

Sharks don't have webbed feet! (Laelaps - USA)

Couples faces grow more alike as they age (Mind Hacks - USA)



















Advent of CG in movies (Orbital Teapot - USA)

Mental health simplified (Sporula - USA)

Thursday, July 26, 2007

Shape Of My Heart

My web counter at the bottom of the page tells me that Fresh Brainz has served over 30,000 fresh waffles to our satisfied customers. Another milestone reached!

Thank you Fresh Brainz fanz!

So here's another hot, delicious waffle just for you (with strawberry toppings of course).

Click on the waffle to go to a cool mathematics blog:













And as a token of my appreciation, I shall show you the shape of my heart.

No, I mean literally.

Regular readers already know that I have irregular brainz, but guess what - I have irregular heartbeats too!

Don't worry, I'm not dying yet!

(Though Dr. Daneeka would say: "Of course you are. We all are.")

But it occurs so often that it's annoying and depressing, so I went to see a doctor about it.

She recommended a chest doppler echo.

In layman's terms it's called a "heart ultrasound scan".

Funny how the layman's version sounds more techie than the medical version.

So three weeks ago I went for my ultrasound.

As part of Fresh Brainz's public service - I will briefly describe the process!

1. The whole procedure takes about 45 min. So go to the loo first.

2. First they put electrode stickers on you and hook you up to an ECG.

3. Then you have to lie down. Unlike ultrasounds for pregnant mums, you have to lie on your side for the whole procedure.

4. The chief implement of torture is a handheld ultrasound probe that is pressed against three positions on your chest and abdomen. No, I'm kidding. It doesn't hurt at all.

Unless you can hear ultrasonic frequencies.

5. When the recording is complete, you just need to wipe that green gel off your chest and walk away like a real man.

And the result?












Heh, quite a clear picture.

I always thought that ultrasound images needed a fair bit of imagination to visualize, but this one is obvious enough for a layman.

The sonographer said that I have good lungs, which is why the image is relatively noise-free.

Gee thanks! I love a pair of good lungs.


I know that words are the swords of a lawyer

I know that bankers have billions in store

Administrators rule everything from the start

But that's not the shape of my heart

That's not the shape, the shape of my heart

Wednesday, July 25, 2007

Fresh Science 25 July 2007

We do the hard work of zipping around the globe for the tastiest science articles - so you don't have to.

Seven scientist-guinea pigs (Bayblab - Canada)

Homeopathic surgeon kills (Bug Girl's Blog - USA)

Journey to the heart of a cell* (Entertaining Research - India)











Autism, honesty and capacity to deceive (Mind Hacks - USA)

The ladies already knew about our lack, of course (Pharyngula - USA)

*The XVIVO animation displayed in the lecture has been previously featured on Fresh Brainz here:
Superb computer animation of a cell

Tuesday, July 24, 2007

Fresh Science 24 July 2007

We do the hard work of trekking the globe for the most delectable science articles - so you don't have to.

Superstitions are not the province of the uneducated or the foolish (Angry Doctor - Singapore)

What would Newton do? (Bad Astronomy - USA)

Stem cells and cancer, forget everything you know (Bayblab - Canada)

Peace loving, matriarchal, and sexually liberated? (Entertaining Research - India)

Spinning silhouette illusion (Mind Hacks - USA)






















She appears to constantly spin in one direction, but if you concentrate hard enough... voila! She spins in the opposite direction!

Brainz are funny things.

Monday, July 23, 2007

Fresh Science 23 July 2007

We do the hard work of hobnobbing the globe for the most gossipy science articles - so you don't have to.

Weekly World News abducted by aliens! (Bad Astronomy - USA)

Checkers deconstructed (Bayblab - Canada)

Biopunk (Computational Biology News - India)

The necessity of the brain: a slight return (Mind Hacks - USA)

















Three Rivers Rock & Fossil Museum (The Flying Trilobite - Canada)

Sunday, July 22, 2007

Stripper, Blogebrity or Systems Engineer?

This woman is now the hottest blogger in Hong Kong.

Her blog is read by over 100,000 people a day.

And she hasn't even updated it since January.

Of course you are asking: WHY?!!
















She is Louis Vuitton Yumiko, who also goes by Coco (because she looks like popstar Coco Lee) - a buxomly 20-year-old nightclub hostess involved in a sex scandal three weeks ago.

Her real name is Liu Yao. She used to work in a karaoke club called "Must Kara" at Causeway Bay in Hong Kong, where she would don wigs and perform striptease dances for wealthy clients.

Then on the 5th of July, an embarrassing accident happened.

Chu Pui-Hing, Director of Broadcasting at Radio Television Hong Kong, visited the Must Kara club with his friends.

He is married with two kids.

At the club, Mr. Chu was so enamored of Coco that he

... repeated praisedly (sic) her beauty and kept his hands on her breast.

He paid thousands of dollars for Coco to perform an exotic dance with her brunette wig.

Impressed, he then paid thousands more to take her out.

As they were walking towards Coco's apartment, the media chief was suddenly spotted by a group of reporters who were covering Kenny Bee's concert nearby.

The photographers went into immediate action.

And this is the result.
















Mr. Chu ducked for cover behind Coco, still hanging on to her wig. Meanwhile Coco appeared pleasantly surprised in all the photos, probably because she had no idea who Mr. Chu was.

He later ran away and hid in the toilet of a restaurant.

But it was too late.

He had been recognized and his photos splashed all over the tabloids.

Because of the media fallout from this debacle, Mr. Chu resigned from his post, ten months ahead of his planned retirement.

His career was over.

Coco, on the other hand, immediately shot to fame. Her blog, which includes some photos of her wearing tantalizingly little, is swarmed by a few hundred thousand readers within days.

She is currently lying low in her hometown of Sichuan, China to avoid unwanted attention. But she still hopes to return to Hong Kong and become a top Mama-san someday.

You are thinking: "Now just wait a minute... Why are you featuring this piece of schadenfreude trash news? Is it merely because Coco is now the top blogger in Hong Kong?"

Not quite.

Fresh Brainz is featuring Coco the stripper/blogebrity extraordinaire because of what she wrote in her blog:
















任何一种选择都不可能结局完美,就比如选择了典雅的高根鞋便放弃了舒适的平底鞋. 当香烟爱上火柴..就注定被它伤害..点的是烟..伤的是心!

女人..无所谓正派..正派是因为受到的诱惑不够..

男人..无所谓忠诚..忠诚是因为背叛的筹码不够..

Oops, I forgot that 99% of Fresh Brainz readers don't read Chinese, so here is my (not very arty) translation:

There isn't any one choice that gives a perfect outcome, for instance by choosing elegant high heel shoes one has to give up comfortable flat shoes. When a cigarette falls in love with a match, it is destined to be hurt by it.. what lights up is smoke.. but what hurts is the heart!

Women.. there isn't any so-called decent woman.. she is decent only because she hasn't been tempted enough.

Men.. there isn't any so-called faithful man.. he is faithful only because he doesn't have enough bargaining chips for betrayal.


Her first line sounds strangely familiar!

Just check out this paragraph from a systems engineering website:






What is Systems Engineering?

The word optimal should not appear in the statement of the problem, because there is no single optimal solution to complex systems problems. Most system designs have several performance and cost criteria.

Systems Engineering creates a set of alternative designs that satisfy these performance and cost criteria to varying degrees. Moving from one alternative to another will usually improve at least one criterion and worsen at least one criterion, i.e. there will be trade-offs.

None of the feasible alternatives is likely to optimize all the criteria. Therefore, Systems Engineers must settle for less than optimality.

No complex system is likely to be optimal to all the people, all the time.


So Coco is a stripper/blogebrity/systems engineer?

Oh the humanity!

Heh.


Would you like to know more?
-
RTHK chief quits amid media frenzy

Fresh Science 22 July 2007

We do the hard work of checking the globe for the most succulent science articles - so you don't have to.

The journal of irreproducible results (Bayblab - Canada)

Photos from the American Museum of Natural History (Laelaps - USA)














Understanding anaesthetics better (Pro-science - Denmark)

A quickie about dinosaurs not being... well quickie (Sporula - USA)

You can always trust an amphipod to survive the ice age (The Other 95% - USA)

Friday, July 20, 2007

Fresh Science 20 July 2007

We do the hard work of nitpicking the globe for the naughtiest science articles - so you don't have to.

Cockapoos threatening kakapos (Bayblab - Canada)















Chikken Tikkas and Alzheimer's! (Microarray Blog - India)

Brain haemorrhage inspires creativity (Mind Hacks - USA)

Rearing a well-adjusted Superorganism (Orbital Teapot - USA)

Review of Tyrannosaur Canyon (The Ethical Palaeontologist - UK)

Thursday, July 19, 2007

Need More Rain

The past month felt like a huge, island-wide sauna.

32 degrees Celsius.

At night.

Well, at least it rained quite a bit this morning, with a bonus cool breeze that I haven't felt for weeks.













And when it rains it doesn't rain enough,

I often think we get it too rough,

Get up and see the perspiration 'round my eyes.


Sounds like a song.


Would you like to know more?
- Weather and romance

Fresh Science 19 July 2007

We do the hard work of combing the globe for the nuttiest science articles - so you don't have to.

Chess on rollercoasters (Bayblab - Canada)

How to be in the snob-free zone (Entertaining Research - India)

An artistic impression of alcoholic delirium (Mind Hacks - USA)













We all seem to be in an arithmetic mood today (Pharyngula - USA)

The Last Question* (Scientifically Open Source - USA)

*Superb short story by Isaac Asimov. Highly recommended!

Wednesday, July 18, 2007

Fresh Science 18 July 2007

We do the hard work of rummaging the globe for the fluffiest science articles - so you don't have to.

Cracking a scientific nut (Bad Astronomy - USA)

Stretching myths (Bayblab - Canada)















Unconscious beauty primes positive emotions (Mind Hacks - USA)

Two negatives make one positive? (Scientifically Open Source - USA)

Total Drek tips for publishing journal articles (Total Drek - USA)

Tuesday, July 17, 2007

One Word - Many Evolutions

Evolution just means "change".

Just like amigos para siempre means "you'll always be my friend".

And amics per sempre means a love that cannot end.

*cough*

As I was saying, evolution is a general term used to describe any process of change or formation.

Opponents of science, especially creationists, are so accustomed to their monolithic belief systems that they tend to lump all scientific fields together into a single, monolithic bloc.

Good for the ol' one-to-one dick fight.

Creation vs Evolution!

Faith vs Human Reason!

Great for selling tickets.

In reality, scientists construct our current understanding of the Universe piece by piece, from different disciplines, using different approaches and techniques.

It's not a house of cards, where finding a single weakness can bring the whole shebang down.

Each field has its own stacks of data to back up their main theory, and each one stands on its own merit.

In order to refute all evolutionary theories in science, no amount of rhetoric or politicking is enough. You'll need tonnes of evidence and brand new theories that have better explanatory power, clearer mechanisms and more superior predictive capabilities than all existing theories.

This means "many painful years of work".

We should be cautious of theories that cannot (or need not) be tested experimentally. Or "scientists" who don't do any original research.

So, when creationists attack evolution as if it is a monolithic theory, they are actually up against all these "evolutions" (and one non-evolution):

1. Evolution of the Universe

Scientific field: Physics
Techniques used: astronomical observations, cosmic background radiation, abundance of primordial elements...
Current theory: Big Bang


Doesn't it sound crazy? Our entire Universe just popped into existence billion of years ago from a singularity. Most physicists in the 1930s thought so too.

They were more comfortable with the idea of an eternal Universe until George Lemaitre snapped them out of their worldviews and expanded their minds.

Did I forget to mention the gobs of evidence needed to convince his colleagues? To rock the state of steadiness in his scientific rivals?

More than 70 years later, few scientists will bat an eyelid to the suggestion that our Universe is almost 14 billion years old. In addition, this theory fits quite well with many belief systems.

Unfortunately, there are people who will pick and choose what they believe from any idea.

Some people accept that the Universe has a beginning, but insist that the Universe is only 6000 years old.

Why, that's like ordering an egg bacon spam and sausage without the spam.

Lovely spam!

2. Evolution of the Solar System

Scientific field: Physics
Techniques used: astronomical observations, planetary/meteoroid chemical composition...
Current theory:
Solar Nebula

When you give yourself some spin - the entire Universe seems to revolve around you.

Which is why once the Earth was unseated as the centre of the Universe, the Sun immediately filled that role.

Although we now know that our Sun is just an average star in a remote corner of our galaxy (if spirals can have corners), its importance should not be underestimated.

Without the Sun, the planets wouldn't exist.

They wouldn't be orbiting the Sun in nearly circular, prograde (counter-clockwise from north pole) orbits.

There wouldn't be any atoms to make our bodies.

There wouldn't be any energy to keep us warm.

There wouldn't be any light for plants to make our food.

Without the Sun, we would not be here.

We would be somewhere else, making our Star the centre of the Universe.

Thank the Lords of Kobol!

3. Origin of Life on Earth

Scientific field: Chemistry/Biochemistry
Techniques used: Miller-Urey type experiments...
Current theory:
Abiogenesis

The origin of life does not require an evolutionary theory.

It may be statistically improbable, but it only had to happen once. Scientists are already able to create complex organic components in the lab. They may be able to artificially assemble a single-celled organism soon.

However, the origin of intelligent life is still a big mystery.

Hopefully we will be able to learn more about it, once it happens.

4. Biological evolution (molecular)

Scientific field: Biology/Biochemistry
Techniques used: sequence analysis, genetic experiments...
Current theory:
Neutral Drift

I think Darwin has been unfairly singled out for criticism by creationists.

After all, it's partly Wallace's fault too.

Besides, creationists overestimate the reverence that scientists feel for Darwin.

Real scientists don't worship Darwin (as much as they worship chocolate).

If they did, then why did they throw out his beautiful blended inheritance idea in favour of an Austrian monk who probably falsified his results?

If they really worshipped Darwin, then why didn't they throw out the neutral theory of molecular evolution and remove all traces of it from modern biology textbooks?

Instead, neutral drift became the foundation of the molecular clock technique and modern population genetics.

Scientists continue to bicker over the relative importance of selection vs neutral drift at the molecular level.

Why were anti-selectionists like Kimura and Ohta accorded the kind of respect in the scientific community that creationists never got?

There could only be one reason.

"What do you mean, Doc? All the best stuff's made in Japan."

5. Biological evolution (phenotypic features)

Scientific field: Biology
Techniques used: animal models, molecular genetics, comparative anatomy, fossil record...
Current theory:
Modern Synthesis/Neutral Drift

One of the first criticisms I've heard about Darwinian natural selection is that it employs circular reasoning.

For example, when trying to explain a feature of an animal, for example a wing on a flightless bird:

"The reason why it exists is because it is adaptive! We know it must be adaptive because it exists!"

That's rather unfair to Darwin too, because he predicted the existence of selectively neutral characteristics right from the start. Pan-selectionists are a rare breed nowadays.

Natural selection is effective at shaping phenotypic features that impact survival and reproductive fitness, but not so efficient at removing features that don't matter either way.

In fact the harder we look, the more neutral features we find.

Take an onion for example. Why would it need five times more non-coding DNA than human beings?

Onions have layers!

Ogres have layers!

Yes, and parfaits are indeed delicious.

6. Biological evolution (population level)

Scientific field: Biology
Techniques used: animal models, molecular genetics, comparative anatomy, fossil record...
Current theory:
Modern Synthesis

What creationists don't seem to understand is that evolutionary biology has moved on quite a bit since Darwin's time.














This is why the current evolutionary theory is called the Modern Synthesis.

Which also means that any future improvements will have to be called the Postmodern Synthesis - philosophers rejoice!

Heh.

Modern evolutionary theory differ from Darwin's original idea in three ways (from TalkOrigins):

a. It recognizes several mechanisms of evolution in addition to natural selection. One of these, random genetic drift, may be as important as natural selection.

b. It recognizes that characteristics are inherited as discrete entities called genes. Variation within a population is due to the presence of multiple alleles of a gene.

c. It postulates that speciation is (usually) due to the gradual accumulation of small genetic changes. This is equivalent to saying that macroevolution is simply a lot of microevolution.

While the modern synthesis accounts for much of the experimental data, occasionally we can find some bizarre organisms that present some interesting challenges.

For instance the vole. How did the ancestor of these small rodents manage to diverge into 60 species in just 2 million years - with all the descendants looking virtually identical?

There is reproductive isolation without much phenotypic variation - quite a mystery indeed!

A splendid opportunity to slog for many years in a lab, discovering new improvements to the modern synthesis.

Luckily for most creationists, they don't care enough about science to find supporting evidence for what they already believe.

7. Social and cultural evolution

Scientific field: Biology, Psychology, Sociology, Anthropology
Techniques used: social animal models, observations of social behaviour, archaeological findings...
Current theory:
Lamarckian/Darwinian

In addition to their direct contributions to biology, Darwin and Wallace raised our consciousness (Richard Dawkin's favoured phrase) on the applicability of evolutionary ideas to other fields.

Naturally, the mechanism of cultural evolution is different from biological evolution. Here, Darwin's "survival of the fittest" meets Lamarck's "use it or lose it" and together they help explain how certain cultural behaviours spread so quickly and so widely.

Evolutionary ideas have been used in computer science and engineering as well.

Indeed they have become so integral to many aspects of modern science and technology that creationists have a long road ahead if they wish to refute all of these evolutions.

I suggest starting on non-coding DNA.

In the meantime, they should avoid all new drugs and technologies that are produced by evolutionary ideas, just to be on the safe side.


Would you like to know more?

-
Top ten misunderstood terms in biology
-
Top five reasons why science is t3h l33t
-
Most abused catchphrases in science

Monday, July 16, 2007

Fresh Science 16 July 2007

We do the hard work of zig-zagging the globe for the weirdest articles - so you don't have to.

Human exploration of Phobos and Deimos? (Bad Astronomy - USA)

Snail toxin as pain killer (Computational Biology News - India)

Photographing delusions (Mind Hacks - USA)

The museum of scientifically accurate fabric brain art (Neurodudes - USA)













Horrendously antiquated illustrations (The Lord Geekington - USA)

Saturday, July 14, 2007

VivoCity Photo Gallery

The biggest shopping mall in Singapore, VivoCity, held a photo competition in June.

Photographers have to highlight unique aspects of its architecture, or capture the emotions and energy of the people who come to the mall to shop and play.

Oooh the combination of photography and shopping - it's almost intoxicating! (Just add chocolate and I'm drunk).

How can I let this opportunity pass? How can!??!

So I submitted a selection of my best photos.

This is a very popular competition - almost 1600 photos were submitted ...














... and two of my photos were selected for the semi-finals!

WOO HOO!

Who would've guessed?

A total of 60 photos entered the semi-finals, 20 each in three categories: professional, amateur and student. I'm in the student category, of course. Shortlisted entries are displayed at Level 1, near the main entrance, from 13 - 21 July 2007.

This is the first time that my photographs have been displayed in public as physical prints.

Boy am I excited! Let's take a quick walk through the exhibition.













Here is the panel of photos from the professional category. You immediately know that you are looking at professional photos because of the high quality of these prints. Photos are tack sharp, accurately exposed and very carefully composed.

Some of the photographs are taken from very obvious angles that any casual shooter can pick, for example the VivoCity facade. However the execution is impeccable; you can almost see the years of technique building that goes into each photo.












In contrast, photos from the amateur and student (above) categories have less consistent quality, with prints that range from not-so-sharp to those that looked over-processed.

What they lack in quality, they make up in unique angles and occasionally a quirky sense of humour. When looking through these photos I sense unpolished creativity and a spirit of adventure.

Me likes!














Which is why I'm so proud of this photo that shows two blokes chatting under a huge, arch-shaped shelter. I noticed this angle months ago, and I'm still amazed that no one else saw it.

Even if I don't win anything, my monumental contribution to VivoCity will be this shooting angle - guaranteed to be a hit amongst wedding photographers.

Heh.













I don't think my other photo, which is a straightforward shot of the "collagen triple helix" is any special.

However, while chatting with two people there, they told me that they prefer this photo. I guess it looks more like abstract art with its weird curves and colours.

They thought that I digitally processed the colours, but I didn't - all I did was reduce its brightness.

When in doubt... under-expose!

Now that we've taken a look at the two accepted entries, Fresh Brainz is happy to bring you: the OTHER photos I didn't submit.

Those photos stuck in limbo between "not bad" and "fairly OK" that I deemed not spectacular enough (or too quirky) for the competition.

Now that I see them again, they are really not bad.

Enjoy!











Blue curve












Overlooking Sentosa


















Snowman and the Moon


















Lines & curves


















One blue tile


















Green & silver


















Fire, water & glass


















Silhouette of a tree

If you are free sometime this week, why not pop over to VivoCity and take a look at the exhibition? You can predict the winners by SMS and stand a chance to win an Olympus camera for yourself.

Goodies!


Would you like to know more?

-
Viva la VivoCity
-
Photo Gallery One
-
Photo Gallery Two

Fresh Science 14 July 2007

We do the hard work of ruffling the globe for the snappiest science articles - so you don't have to.

Killer monkey angel! (Bad Astronomy - USA)

Science classrooms are for science (Bayblab - Canada)

Checklist for quacks (Globalizati - USA)

Happy Lacertilian / Evolution takes six years (The Ethical Palaeontologist - UK)













Graduate School: It's everywhere you don't want to be (Total Drek - USA)

Friday, July 13, 2007

Fresh Science 13 July 2007

At Fresh Brainz, we do the hard work of searching the globe for the hottest science articles - so you don't have to.

Queen Procrastinator - PhD after 36 years (Times Online - UK)










More moles mean longer life? (Bayblab - Canada)

Terrorism fails because we don't see its purpose (Mind Hacks - USA)

Fun with Trilobites! (The Flying Trilobite - Canada)

Thursday, July 12, 2007

Fresh Science 12 July 2007

At Fresh Brainz, we do the hard work of tickling the globe for the crunchiest science articles - so you don't have to.

Discover new galaxies! (Bad Astronomy - USA)

Are your bugs sexy? (Bayblab - Canada)

An opportunity for ID to be scientific (Genomicron - Canada)

John Nash speaks to American psychiatry / Phallic Freudian Pops (Mind Hacks - USA)
















What the hell is a chaetognath? (The Other 95% - USA)

Wednesday, July 11, 2007

Fresh Brainz 1st Birthday!

Fresh Brainz is ONE year old today!

The mascots have turned up en masse for the celebration. Nick, Brad, Pikaia, Svetlana and Sally are here ...


















... and oooh there's chocolate truffle cake for everyone. But before I light the candle, let's take a quick walk down memory lane!











Fresh Brainz was not my first attempt at a science & entertainment periodical. Many years ago, I created a newsletter called GIS-Celle which was supposed to inform and amuse fellow researchers.

Unfortunately it never took off and died after two issues.

Its highest readership was five people. Including me.

Heh.











Despite its happy-go-lucky quirkiness, Fresh Brainz was born from despair. It rose out of the ashes of disillusionment and the ruins of my devastated self-esteem.

Instead of spreading misery around by ranting aimlessly like some MySpace blog, I decided to salvage whatever creativity that's left from my emotional wreckage and write science articles that are easy to read and somewhat funny too.

Freshbrainz.blogspot.com opened its doors on 11 July 2006 and was immediately read by (you've guessed it!) five people daily.











This is how Fresh Brainz looked like after it moved to Blogger Beta back in September 2006 ...












... and this is how it looked like in June 2007.

Today, Fresh Brainz has 182 posts and is read by 100 readers daily.

This is a modest achievement, but fellow science bloggers know that building readership in this niche area is an arduous endeavour.

Top science blogger Prof. PZ Myers suggests that a new blogger should be patient:

The key words are fearlessness and persistence. Readers will reward you for speaking your mind - no matter how controversial you might be - but it takes a long, long time to build up a presence on the Web.

Without the support of fellow bloggers, my family, friends and lab mates, Fresh Brainz could not have lasted this long.

I would like to thank my supporters:

Dr. Andrew Thompson
Jonathan Loh
A*Na
WL
AH
PG
JC
BS
PL
SX
RT
PG
JT


I must also thank these bloggers who provided a much needed confidence boost during the early days:

Andrew Tingle (Thoughts From The Sidelines)
Patty (Sea Blue Green)
Mathia Lee (Aaeskay's Blog)
Jeremy Barker (Popped Culture)
Sivasothi (Otterman Speaks)


And to thank some readers who have given me useful advice and encouragement:

Dr. James Mello
SR
DN
LY
AC


*clicks the lighter*

*lights candle*













And of course, a big THANK YOU to all Fresh Brainz readers!

Here, have a slice of chocolate truffle cake.













Bon appetit!

Tuesday, July 10, 2007

A Squirmy Jellyfish

Scientists from Oxford University have discovered that a very rare, gutless, worm-like animal called Buddenbrockia is more closely related to jellyfish than to worms.

First described in 1851, Buddenbrockia is a bizarre animal because it is missing many features that true worms should have.












Lead scientist Prof. Peter Holland explained that:

"It has no mouth, no gut, no brain and no nerve cord. It doesn’t have a left or right side or a top or bottom – we can’t even tell which end is the front!"

Unlike true worms such as planarians, which I've blogged about before, Buddenbrockia doesn't have different specialized organs on different sides of its body.

Prof. Holland added that:

"Buddenbrockia is very unusual in not displaying this kind of body asymmetry. Seen in cross section it is completely symmetrical so no way is ‘up’ and no direction is ‘forward’."

So it IS made up of the same mushy meat throughout its body.

Based on DNA analysis, Prof. Holland's team discovered that Buddenbrockia is more closely related to jellyfish and sea anemone.

Which means that it is classified under the Phylum Cnidaria, a group of animals that are diploblastic - they have two embryonic germ layers: endoderm and ectoderm.

Other animals, such as true worms and vertebrates like us, are classified in a group called Bilateria. Such animals are triploblastic, containing three embryonic germ layers: endoderm, mesoderm and ectoderm.

So this is a particularly striking example of convergent evolution, where animals from different phyla can end up with the same body shape.

While Buddenbrockia is a diploblastic animal like the jellyfish, it doesn't appear to have an opening of any sort.

Perhaps it is tiny enough to absorb nutrients from the environment through its surface.

Jellyfish are not so lucky.

As Cervantes (from Stayin' Alive) describes in excruciating detail:

"You may have noticed that one thing that all of the triploblastic organisms have in common is a gut, a hollow tube running through the body. The food goes in one end, gets serially disassembled and the useful components absorbed, and the waste goes out the other end.

That is a major innovation, and for those contemplating possible options for reincarnation, it's a good reason to request not to come back as a diploblastic jellyfish. (Thanks to Jan Pechenik for this observation.) The food comes in, and the waste goes out, through the same opening. Life without an anus is clearly inferior. Not only is it impossible to take a meal until the last one has been discharged, but movement involves physical distortion of the digestive cavity and expulsion of much of what is in there. So, you can't digest and swim at the same time. Finally, you have to discharge your gametes and embryos through the same opening. Yuck.

So, let's hear it for one of our most important body parts, that gets very little respect."

Dammit I was eating.


Would you like to know more?

About other bizarre organisms
-
Magnetic bacteria
-
Planarian worm
-
Vole

Monday, July 09, 2007

Tagged!

I've been tagged by the long beak of Hawks!

Although I'm not much into chain mail (except when Samantha Mumba is wearing it) , I'll let this one slip.


















1. We have to post these rules before we give you the facts.
2. Players start with eight random facts/habits about themselves.
3. People who are tagged need to write their own blog about their eight things and post these rules.
4. At the end of your blog, you need to choose eight people to get tagged and list their names.
5. Don't forget to leave them a comment telling them they're tagged, and to read your blog.

And here are 'em random facts!

1. Fresh Brainz was inspired by an insane British science show called Brainiac.

This entire blog is littered with references to British comedies (Brainiac, Blackadder, Monty Python, Whose Line Is It Anyway, Wallace and Gromit...) and American comedies (George Carlin, Saturday Night Live, Daily Show...).

2. I have conscious control over my left lower eyelid twitch muscle. I can pull my lower eyelid inwards at will. Nobody else I know has this ability.

If some people have doubts about evolutionary biology, I'll show them my eyelid and freak them out.

3. I was born a left-hander. My parents encouraged me to use my right hand more and I "switched over" as a little kid.

4. In 1990 I won my secondary school's Talentime competition. Even today I don't go to Karaoke much because other people really hate me when I sing.

By the way Karaoke is pronounced as "Ka La Okay", not "Carry Okie".

5. In 1994 I experienced "sidereal depth" when looking at the Moon and Venus. Celestial objects normally look like they are about the same distance away, "pasted" on the flat blue sky.

One morning, while taking a bus to school I looked at the Moon and Venus, and suddenly... WHOOOSH! Venus receded into the distance and I could feel how far away it is, compared to the Moon.

I haven't experienced that feeling again.

6. In July 1999 I saw a UFO above the skies of Singapore.

During the day, it lingered at around the same position in the sky and changed colour (towards red) in the evening. I asked the Meteorological Service if it was a weather balloon, but got no reply. When I pointed a binocular at it, I could faintly see a "U"-shaped silhouette and what looks like two green exhaust ports on the top of the "U". It disappeared after a few days.

I don't know if aliens exist, but if they do, they certainly have a stupid sense of humour.

7. I was once a Playstation horror game addict. I've played all the Silent Hill games, the Fatal Frame series, Forbidden Siren series, Echo Night series, Kuon and others. Earlier this year I played a new horror game called Rule of Rose, which appeared quite innocent in the beginning and became so frighteningly mad that I had nightmares for a week.

Rule of Rose is the only horror game I didn't finish.

8. I get lucid dreams a few times a year. In most of them, I am flying around breaking fragile things like neon signs and windows with my mind.

My favourite lucid dream involved two extremely beautiful and extremely naked women.

And a hot tub.

The next eight hapless victims are:

Anders Rasmussen Blog

Bayblab

Globalizati

Orbital Teapot

The Empire of the Odd

The Ethical Palaeontologist

The Lord Geekington

The Other 95%

*cough*

Sunday, July 08, 2007

What Doesn't Kill You Lets You Live

Sometimes I sit in the lab and think to myself:

"What am I doing here? I'm panning for specks of gold in an abandoned gold mine! There is nothing important left to discover; I'm wasting my time on picky details that nobody will care about!"

Then suddenly, like a huge rubber anvil, a bizarre new scientific discovery fell out of the sky and twacked me on the head.

*BOP!*

Oww!

Last month, the Encyclopedia of DNA Elements (ENCODE) Project Consortium published their findings on 1% of the human genome (about 30 million base pairs).

They were focusing on the regions of the genome that do not encode for proteins, and used a barrage of high-throughput genomics technologies to identify and catalogue functional DNA sequences.

They expected to discover new transcription start sites and non-protein coding transcripts. They also expected that the presence and activity of transcription start sites will be related to chromatin accessibility and histone modifications.

And they were right.

In the evolutionary aspect of their project, they compared the DNA sequences of 14 mammal species with 14 non-mammal vertebrates. They found that 5% of the human genome was highly similar in all mammals (evolutionary constraint). Within these constrained regions, only about 60% of the sequence had evidence of biological function.

Which is rather odd, since highly conserved sequences are expected to be functional. Why would a good 40% of the sequence be conserved if they had no function?

Stranger still, they then discovered that approximately 50% of functionally important non-coding DNA sequences were NOT constrained.

Mammals are using vastly different sequences for essentially the same functions.

In other words: functional conservation without sequence conservation.

Now that is weird.

The researchers noted that (italicized by me):

Surprisingly, many functional elements are seemingly unconstrained across mammalian evolution. This suggests the possibility of a large pool of neutral elements that are biochemically active but provide no specific benefit to the organism. This pool may serve as a ‘warehouse’ for natural selection, potentially acting as the source of lineage-specific elements and functionally conserved but nonorthologous elements between species.

I knew it!

Heh.

Mainstream evolutionary theory would have you believe that many (if not all) features of a living organism were "fine-tuned" by natural selection to be well-adapted to its environment.

You get the feeling that the organism is under such massive selection pressure that natural selection would efficiently prune away useless DNA sequences and preserve only the sequences that helped the organism to survive. This is true for protein-coding sequences, which tends to be highly conserved from fish to human beings.

We are all built from roughly the same building blocks.

So it was generally assumed that all conserved DNA sequences ought to be functionally important. However, the wide variation in total genome size is a clue that non-coding sequences do not play by the same rules.

To take two extreme examples: the grasshopper Podisma pedestris has about six times (18 Gbp) the total genome size of a human, while the tiny shrimp-like Ampelisca macrocephala has nearly 20 times (63 Gbp) our genome size!

In fact there is a 3 300-fold difference between the largest and smallest animal genomes.

There is no correlation between genome size and the number of protein-coding genes (which is much less variable, around 10-fold) in animals.

Our building blocks are arranged and used in different ways.

And because animals are complex systems with redundant genes and many organizational levels, it's hard to pin biological function all the way down to the DNA sequence level.

So I don't find it surprising that there are many neutral elements in the human genome. Considering the robustness of even a single cell, the reality is that Nature tolerates many variations at the sequence level, and natural selection won't remove even huge chunks of DNA if they don't kill the organism fast enough to stop it from reproducing.

To oversimplify:

What doesn't kill you, lets you live.

It usually doesn't make any difference and it rarely makes you stronger.

As for functional conservation without sequence conservation - structural biologists are already aware of this at the protein level. Some amino acid sequences are highly conserved, but changes in a few key positions can drastically affect the fold of the protein, so sequence conservation is not enough to guarantee the same function.

The converse is also true - drastically different amino acid sequences can end up having a similar 3D fold and serve similar functions. The EMBL Dali tool is an online resource that allows biologists to submit a protein crystal structure and search for other proteins with a similar 3D shape, no matter what the amino acid sequence is.

With the discovery that so much functionally important DNA has no evolutionary constraint, just knowing the DNA sequence itself is no longer sufficient.

Data from ENCODE and other related research projects may help create a Dali-like tool for non-coding DNA sequences one day.

This could prove quite difficult since the function of non-coding DNA is not just a matter of 3D shape - confounding variables such as the chromatin configuration and the expression timing of specific transcription factors will have to be accounted for.

So there are still some big mysteries left to be solved!

Oh well.

*goes back to panning for gold*


Would you like to know more?

- More about ENCODE

Fresh Science 8 July 2007

At Fresh Brainz, we do the hard work of teasing the globe for the munchiest science articles - so you don't have to.

The spotted hyena puts you to shame (Bayblab - Canada)

Virus linked to temporal lobe epilepsy (Mind Hacks - USA)

Now this is how to critique Ken Ham's creation "museum" (Pharyngula- USA)

Remember Roswell? (The Empire of the Odd - USA)

James Randi explains homeopathy (Alex Feldstein - USA)

Friday, July 06, 2007

Fresh Science 6 July 2007

Here at Fresh Brainz, we do the hard work of screening the globe for the choiciest science articles - so you don't have to.

Penises of the animal kingdom (Bayblab - Canada)

The soul exists but it's made up of billions of tiny robots... (Orbital Teapot - USA)

New example of the problem solving skills of orangutans (Pro-science - Denmark)

They're over here (The Ethical Palaeontologist - UK)

The last common ancestor between squid and octopus? (The Other 95% - USA)

Thursday, July 05, 2007

Fresh Science 5 July 2007

Here at Fresh Brainz, we do the hard work of scanning the globe for the coolest science articles - so you don't have to.

What is "health"? (Aetiology - USA)

You're as cold as ice... but less dense (Bad Astronomy - USA)

Sex or chocolate? (Bayblab - Canada)

And hurricanes are just air and water... /
The two faces of fictional scientists part III (Orbital Teapot - USA)

Saucers in the sky (The Empire of the Odd - USA)

Just a spoonful of Mamenchisaurus to help the medicine go down!
(The Flying Trilobite - Canada)

Wednesday, July 04, 2007

Psychologically Healthy Terrorists

Investigations into the recent terrorist attacks in Britain have revealed that a number of suspects are medical professionals.

Now that's a shocker.

Even a dyed-in-the-wool cynic like myself raised a quizzical eyebrow.

The possibility that highly educated professionals can be involved in terrorist activities is not that surprising for me, because these people ought to be really smart if they are not noticed or caught.

In addition, there have been precedents.

In Singapore, for example, a qualified lawyer who studied at a top junior college and graduated from a local university was arrested when he was about to travel to Afghanistan and join the Taleban. He was "self-radicalized" by extremist websites on the Internet.

But, doctors... not quite the same...

They are healers. We trust our lives with them.

Don't they have to take the Hippocratic Oath of doing no harm?












How can anyone hold such conflicting beliefs and still remain sane?

Perhaps these are especially evil doctors who went to Evil medical school?











Actually, no.

I don't know what new details will emerge from the investigations, but I'll bet that the doctors involved in the attacks are completely normal and psychologically healthy people.

You are thinking: "Psychologically HEALTHY? Are you joking?"

Heh, I joke often.

But not this time.

Years ago when I was studying neuroscience as an undergrad, I took an introductory course about human personalities and social psychology.

I recall that my professor (who is an expert on the interpersonal circumplex) taught us that people who can quickly adapt to the rules of different situations - are the most psychologically healthy individuals.

In contrast, people who use a fixed, consistent set of rules to deal with all aspects of everyday life often have psychological, even neurological problems.

For example, people with mild social phobia may function fine in the presence of friends and family, but are unable to adjust to the new rules of interacting with unfamiliar faces.

At the extreme end, some people with autism are unable to learn any social rules at all.

The lecture ended and everyone went home.

But I felt disturbed by its implications.

I was thinking to myself:

"Does that mean that a two-faced, super-slick, slippery-snake hypocrite is more psychologically healthy than a person of consistent principles and actions?"

At that time I was quite opposed to my professor's opinion, but years later I realize that he is mainly correct.

Only people who are psychologically very healthy can hold two absolutely opposing beliefs and feel no conflict at all. They adapt quickly to the rules and demands of a wide variety of situations, because they feel no need to think consistently or standardize their behaviour.

They are happy, confident and well-adjusted wherever they go.

The best candidates to become terrorists.

When they are playing their role as healers, they are compassionate and dutiful healers. When they are playing their role as killers, they are ruthless and decisive killers.

Lesser people would have cracked under the intense pressure of inner conflict, self-doubt and anxiety. The security forces would have noticed these jittery nervous wrecks from miles away and thwarted their plans.

Everyone loves people of great confidence and charisma, which is why they can do so much good - or do so much damage.

Or even both.

At the same time.


Would you like to know more?

-
Terror suspects not brainwashed
-
Why do extremists exist?

Tuesday, July 03, 2007

Fresh Science 3 July 2007

Here at Fresh Brainz, we do the hard work of combing the globe for the juiciest science articles - so you don't have to.

I hope people don't listen to you (Orbital Teapot - USA)

I haven't enjoyed headphones this much since the sixties (Pharyngula - USA)

Darwinism hurts - but viruses don't (The DesignInterference - New Zealand)

Ugly Phase (The Flying Trilobite - Canada)

Actually, jelly burgers don't sound too bad (The Other 95% - USA)

Monday, July 02, 2007

Fresh Science 2 July 2007

Fresh Brainz is proud to bring you a brand new feature: Daily reads from the science 'o sphere!

Science blog readers may know (and science bloggers definitely know) that good science blogs aren't easy to find.

We do the hard work of scouring the globe for the meatiest science articles, so you don't have to.

What happened before the Big Bang? (Bad Astronomy - USA)

How to solve problems in your PhD (Bayblab - Canada)

Feeling down? Need something? (globalizati - USA)

Bacteria "species" (Sporula - USA)

I knew it! We have worm brains! (The Other 95% - USA)

Enjoy!

Sunday, July 01, 2007

Tour Of The Creation Museum

Andrew Arensburger visited Ken Ham's Creation Museum in early June and posted a comprehensive blog post, complete with maps, photos and an insightful commentary.

Giving us non-Americans a chance to take a close look at the immense scale of the creationist anti-science culture in the USA.

Click on the picture to go to his article.













The quality of the exhibits is so good that I get an eerie feeling of how powerful these creationist groups must be, both politically and economically.

Although I have met a number of "closet" creationists in Singapore, I guess we're lucky that there isn't any organized creationist group here.

Yet.

American creationist groups intend to widen their international influence. Ken Ham, who was born in Australia, revealed that:

... I had this embryonic idea 25 years ago in Australia. But of course, Australia's not really the place to build such a facility if you're going to reach the world. Really, America is.

It's hard to say what will happen in the future.


Would you like to know more?

- New York Times review of the Creation Museum